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Sigma European reference ( University of Copenhagen/ Danish Cancer Society) indicates that SAHA is a hydroxamic acid derivative related to PXD101 and Trichostatin A, which are possible mutagens. Severe eye irritant, with low toxicity via inhalation and skin contact. Sigma Aldrich MSDS AD, Alzheimer’ s disease; PD, Parkinson’ s disease. Studies such as the MEIC programme ( Ekwall et al.
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, 1998 ) and the FRAME cytotoxicity validation study ( Knox et al. , 1986 ) have shown that in vitro basal cytotoxicity assays, based upon cell number, give a 70% predictivity of acute oral rodent LD 50 values.